PUBLICATIONS
2024
PP Janas, C Chauché, P Shearer, G Perona-Wright, HJ McSorley and J Schwarze. Cold dispase digestion of murine lung improves recovery and culture of airway epithelial cells. PLoS One (2024) 19:e0297585.
2023
MC Sinton, PRG Chandrasegaran, P Capewell, A Cooper, A Girard, J Ogunsola, G Perona-Wright, D M Ngoyi, N Kuispond, B Bucheton, M Camara, S Kajimura, C Bénézech, NA Mabbott, A MacLeod and JF Quintana. IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nat Commun (2023) 14:7070.
GA Heieis, TA Patente, L Almeida, F Vrieling, T Tak, G Perona-Wright, RM Maizels, R Stienstra and B Everts. Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helmnith infection. Nat Commun (2023) 14, 5267.
C Pirillo, S Al Khalidi, A Sims, R Devlin, H Zhao, R Pinto, S Jasim, PA Shearer, AL Shergold, H Donelly, A Bravo-Blas, C Loney, G Perona-Wright, E Hutchinson and EW Roberts. Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Sci Immunol (2023) 8:eadg8249.
CL Bennett and G Perona-Wright. Metabolic adaption of mucosal macrophages: Is metabolism a driver of persistence across tissues? Mucosal Immunol (2023) 16, 753--763.
2022
G Perona-Wright and HJ McSorley. Lessons from helminths: what worms have taught us about mucosal immunology. Mucosal Immunol (2022) 15, 1049-1051. An editorial introducing a set of comissioned reviews that discuss key advances made possible by the study of helminth infections.
HC Webster, V Gamino, AT Andrusaite, OJ Ridgewell, J McCowan, AL Shergold, GA Heieis, SWF Milling, RM Maizels and G Perona-Wright. Tissue-based IL-10 signalling in helminth infection limits IFNg expression and promotes the intestinal Th2 response. Mucosal Immunol (2022) 15, 1257--1269.
2021
PA Louwe, L Badiola Gomez, H Webster, G Perona-Wright, CC Bain, SJ Forbes and SJ Jenkins. Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells. Nat Commun (2021) 12, 1770.
E Amiel and G Perona-Wright. Sweet talk: Metabolic conversations betwen host and microbe during infection. Immunology (2021) 162, 121-122.
The second in a series of editorial pieces.
2020
E Amiel and G Perona-Wright. Metabolic mediators: How immunometabolism directs the immune response to infection. Immunology (2020) 161, 163-164.
An editorial piece that leads an exciting series of commissioned reviews, all exploring the immunometabolism of infection.
F Vacca, C Chauché, A Jamwal, EC Hinchy, G Heieis, H Webster, A Ogunkanbi, Z Sekne, WF Gregory, M Wear, G Perona-Wright, MK Higgins, JA Nys, ES Cohen and HJ McSorley. A helminth-derived suppressor of ST2 blocks allergic responses. eLife (2020) 9:e54017.
2019
HC Webster, AT Andrusaite, AL Shergold, SWF Milling and G Perona-Wright. Isolation and functional characterisation of lamina propria leukocytes from helminth-infected, murine small intestine. J Immunol Methods (2019) Nov 6, p 112702.
2018
SA Redpath, GA Heieis, LA Reynolds, NM Fonseca, SS-Y Kim and G Perona-Wright. Functional specialization of intestinal dendritic cell subsets during Th2 helminth infection in mice. Eur J Immunol (2018) 48, 87-98.
2017
BC Lo, MJ Gold, S Scheer, MR Hughes, J Cait, E Debruin, FSF Chu, DC Walker, H Soliman, FM Rossi, M-R Blanchet, G Perona-Wright, C Zaph and KM McNagny. Loss of vascular CD34 results in increased sensitivity to lung injury. Am J Respir Cell Mol Biol (2017) 57, 651-661.
LA Reynolds, SA Redpath, S Yurist-Doutsch, N Gill, EM Brown, J van der Heijden, TP Brosschot, J Han, NC Marshall, SE Woodward, Y Valdez, CH Borchers, G Perona-Wright* and BB Finlay*. Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome. J Infect Dis (2017) 215, 1245-1254. * = co-senior authors
S Scheer, TS Medina, A Murison, MD Taves, F Antignano, AL Chenery, KK Soma, G Perona-Wright, M Lupien, CH Arrowsmith, DD de Carvalho and C Zaph. Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation. J Leukoc Biol (2017) 101, 893-900.
2016
MJ Oudoff, F Antignano, AL Chenery, K Burrows, SA Redpath, MJ Braam, G Perona-Wright and C Zaph. Intestinal epithelial cell-intrinsic deletion of Setd7 identifies a role for developmental pathways in immunity to helminth infection. PLoS Pathog (2016) 12, e1005876.
2015
AL Chenery, F Antignano, K Burrows, S Scheer, G Perona-Wright and C Zaph. Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation. Infect Immun (2015) 84, 491-501.
SA Redpath, G Heieis and G Perona-Wright. Spatial regulation of IL-4 signalling. Cytokine (2015) 75, 51-56.
SL Russell, MJ Gold, LA Reynolds, BP Willing, P Dimitriu, L Thorson, SA Redpath, G Perona-Wright, MR Blanchet, WW Mohn, BB Finlay and KM McNagny. Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. J Allergy Clin Immunol (2015) 135, 100-109.
2014
SA Redpath, NM Fonseca and G Perona-Wright. Protection and pathology during parasite infection: IL-10 strikes the balance. Parasite Immunol (2014) 36, 233-252.
DT Patton, AW Plumb, SA Redpath, LC Osborne, G Perona-Wright and N Abraham. The development and survival but not the function of follicular B cells is dependent on IL-7Ra Tyr449 signaling. PLoS One (2014) 9, e88771.
2012
G Perona-Wright, JE Kohlmeier, E Bassity, T Freitas, K Mohrs, T Cookenham, H Situ, EJ Pearce, DL Woodland and M Mohrs. A persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. PNAS (2012) 109, 18535-18540.
G Perona-Wright, RJ Lundie, SJ Jenkins, LM Webb, RK Grencis and AS MacDonald. Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction. J Immunol (2012) 188, 2350-2358.
2011
JE Kohlmeier, WW Reiley, G Perona-Wright, ML Freeman, EJ Yager, LM Connor, EL Brincks, T Cookenham, AD Roberts, CE Burkum, S Sell, GM Winslow, MA Blackman, M Mohrs and DL Woodland. Inflammatory chemokine receptors regulate CD8+ T cell contraction and memory generation following infection. J Exp Med (2011) 208, 1621-1624.
2010
G Perona-Wright, K Mohrs and M Mohrs. Sustained signaling by canonical T helper cytokines throughout the reactive lymph node. Nat Immunology (2010) 11, 520-526. A synopsis was published as a Research Highlight in Nature Reviews Immunology (2010) 10, 382-383.
G Perona-Wright, K Mohrs, KD Mayer and M Mohrs. Differential regulation of IL-4Ra expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J Immunol (2010) 184, 615-623.
2009
G Perona-Wright, K Mohrs, FM Szaba, LW Kummer, R Madan, CL Karp, LL Johnson, ST Smiley and M Mohrs. Systemic but not local infections elicit immunosuppressive IL-10 production by Natural Killer cells. Cell Host & Microbe (2009) 6, 503-12. An accompanying commentary, written by Eric Vivier and Sophie Ugnoli, was published in the same issue.
B Everts, G Perona-Wright, HH Smits, CH Hokke, AJ van der Ham, CM Fitzsimmons, MJ Doenhoff, J van der Bosch, K Mohrs, H Haas, M Mohrs, M Yazdanbakhsh and G Schramm. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J Exp Med (2009) 206, 1673-80.
KN Couper, PA Lanthier, G Perona-Wright, LW Kummer, W Chen, ST Smiley, M Mohrs and LL Johnson. Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection. J Immunol (2009) 182, 3985-94.
G Perona-Wright, SJ Jenkins, RA O’Connor, D Zienkiewicz, HJ McSorley, RM Maizels, SM Anderton and AS MacDonald. A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. J Immunol (2009) 182, 2808-15.
2008
G Perona-Wright, K Mohrs, J Taylor, C Zaph, D Artis, EJ Pearce and M Mohrs. Helminth infection induces IgE in the absence of m or d chain expression. J Immunol (2008) 181, 6697-701.
SJ Jenkins, G Perona-Wright and AS MacDonald. Full development of Th2 immunity requires both innate and adaptive sources of CD154. J Immunol (2008) 180, 8083-92.
2007
SJ Jenkins, G Perona-Wright, AG Worsley, N Ishii and AS MacDonald. Dendritic cell expression of OX40L acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J Immunol (2007) 179, 3515-23.
S Mahajan, AM Cervera, M MacLeod, S Fillatreau, G Perona-Wright, S Meek, A Smith, AS MacDonald and D Gray. The role of ICOS in the development of CD4 T cell help and the re-activation of memory T cells. Eur J Immunol (2007) 37, 1796-808.
G Perona-Wright, SM Anderton, SE Howie and D Gray. IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease. Int Immunol (2007) 19, 1123-34.
2006
G Perona-Wright, SJ Jenkins, A Crawford, D Gray, EJ Pearce and AS MacDonald. Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol (2006) 36, 2367-75.
G Perona-Wright, SJ Jenkins and AS MacDonald. Dendritic cell activation and function in response to Schistosoma mansoni. Int J Parasitol (2006) 36, 711-21. A review article.
2002
MW Barnett, CE Fisher, G Perona-Wright and JA Davies. Signaling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan. J Cell Science (2002) 115, 4495-4503.
1998
G Fu, G Perona-Wright and DC Barker. Leishmania (V.) braziliensis: characterization of a complex specific repeat and its use in the detection of parasites. Exp Parasitol (1998) 90, 236-43.
2024
PP Janas, C Chauché, P Shearer, G Perona-Wright, HJ McSorley and J Schwarze. Cold dispase digestion of murine lung improves recovery and culture of airway epithelial cells. PLoS One (2024) 19:e0297585.
2023
MC Sinton, PRG Chandrasegaran, P Capewell, A Cooper, A Girard, J Ogunsola, G Perona-Wright, D M Ngoyi, N Kuispond, B Bucheton, M Camara, S Kajimura, C Bénézech, NA Mabbott, A MacLeod and JF Quintana. IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nat Commun (2023) 14:7070.
GA Heieis, TA Patente, L Almeida, F Vrieling, T Tak, G Perona-Wright, RM Maizels, R Stienstra and B Everts. Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helmnith infection. Nat Commun (2023) 14, 5267.
C Pirillo, S Al Khalidi, A Sims, R Devlin, H Zhao, R Pinto, S Jasim, PA Shearer, AL Shergold, H Donelly, A Bravo-Blas, C Loney, G Perona-Wright, E Hutchinson and EW Roberts. Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Sci Immunol (2023) 8:eadg8249.
CL Bennett and G Perona-Wright. Metabolic adaption of mucosal macrophages: Is metabolism a driver of persistence across tissues? Mucosal Immunol (2023) 16, 753--763.
2022
G Perona-Wright and HJ McSorley. Lessons from helminths: what worms have taught us about mucosal immunology. Mucosal Immunol (2022) 15, 1049-1051. An editorial introducing a set of comissioned reviews that discuss key advances made possible by the study of helminth infections.
HC Webster, V Gamino, AT Andrusaite, OJ Ridgewell, J McCowan, AL Shergold, GA Heieis, SWF Milling, RM Maizels and G Perona-Wright. Tissue-based IL-10 signalling in helminth infection limits IFNg expression and promotes the intestinal Th2 response. Mucosal Immunol (2022) 15, 1257--1269.
2021
PA Louwe, L Badiola Gomez, H Webster, G Perona-Wright, CC Bain, SJ Forbes and SJ Jenkins. Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells. Nat Commun (2021) 12, 1770.
E Amiel and G Perona-Wright. Sweet talk: Metabolic conversations betwen host and microbe during infection. Immunology (2021) 162, 121-122.
The second in a series of editorial pieces.
2020
E Amiel and G Perona-Wright. Metabolic mediators: How immunometabolism directs the immune response to infection. Immunology (2020) 161, 163-164.
An editorial piece that leads an exciting series of commissioned reviews, all exploring the immunometabolism of infection.
F Vacca, C Chauché, A Jamwal, EC Hinchy, G Heieis, H Webster, A Ogunkanbi, Z Sekne, WF Gregory, M Wear, G Perona-Wright, MK Higgins, JA Nys, ES Cohen and HJ McSorley. A helminth-derived suppressor of ST2 blocks allergic responses. eLife (2020) 9:e54017.
2019
HC Webster, AT Andrusaite, AL Shergold, SWF Milling and G Perona-Wright. Isolation and functional characterisation of lamina propria leukocytes from helminth-infected, murine small intestine. J Immunol Methods (2019) Nov 6, p 112702.
2018
SA Redpath, GA Heieis, LA Reynolds, NM Fonseca, SS-Y Kim and G Perona-Wright. Functional specialization of intestinal dendritic cell subsets during Th2 helminth infection in mice. Eur J Immunol (2018) 48, 87-98.
2017
BC Lo, MJ Gold, S Scheer, MR Hughes, J Cait, E Debruin, FSF Chu, DC Walker, H Soliman, FM Rossi, M-R Blanchet, G Perona-Wright, C Zaph and KM McNagny. Loss of vascular CD34 results in increased sensitivity to lung injury. Am J Respir Cell Mol Biol (2017) 57, 651-661.
LA Reynolds, SA Redpath, S Yurist-Doutsch, N Gill, EM Brown, J van der Heijden, TP Brosschot, J Han, NC Marshall, SE Woodward, Y Valdez, CH Borchers, G Perona-Wright* and BB Finlay*. Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome. J Infect Dis (2017) 215, 1245-1254. * = co-senior authors
S Scheer, TS Medina, A Murison, MD Taves, F Antignano, AL Chenery, KK Soma, G Perona-Wright, M Lupien, CH Arrowsmith, DD de Carvalho and C Zaph. Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation. J Leukoc Biol (2017) 101, 893-900.
2016
MJ Oudoff, F Antignano, AL Chenery, K Burrows, SA Redpath, MJ Braam, G Perona-Wright and C Zaph. Intestinal epithelial cell-intrinsic deletion of Setd7 identifies a role for developmental pathways in immunity to helminth infection. PLoS Pathog (2016) 12, e1005876.
2015
AL Chenery, F Antignano, K Burrows, S Scheer, G Perona-Wright and C Zaph. Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation. Infect Immun (2015) 84, 491-501.
SA Redpath, G Heieis and G Perona-Wright. Spatial regulation of IL-4 signalling. Cytokine (2015) 75, 51-56.
SL Russell, MJ Gold, LA Reynolds, BP Willing, P Dimitriu, L Thorson, SA Redpath, G Perona-Wright, MR Blanchet, WW Mohn, BB Finlay and KM McNagny. Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. J Allergy Clin Immunol (2015) 135, 100-109.
2014
SA Redpath, NM Fonseca and G Perona-Wright. Protection and pathology during parasite infection: IL-10 strikes the balance. Parasite Immunol (2014) 36, 233-252.
DT Patton, AW Plumb, SA Redpath, LC Osborne, G Perona-Wright and N Abraham. The development and survival but not the function of follicular B cells is dependent on IL-7Ra Tyr449 signaling. PLoS One (2014) 9, e88771.
2012
G Perona-Wright, JE Kohlmeier, E Bassity, T Freitas, K Mohrs, T Cookenham, H Situ, EJ Pearce, DL Woodland and M Mohrs. A persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. PNAS (2012) 109, 18535-18540.
G Perona-Wright, RJ Lundie, SJ Jenkins, LM Webb, RK Grencis and AS MacDonald. Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction. J Immunol (2012) 188, 2350-2358.
2011
JE Kohlmeier, WW Reiley, G Perona-Wright, ML Freeman, EJ Yager, LM Connor, EL Brincks, T Cookenham, AD Roberts, CE Burkum, S Sell, GM Winslow, MA Blackman, M Mohrs and DL Woodland. Inflammatory chemokine receptors regulate CD8+ T cell contraction and memory generation following infection. J Exp Med (2011) 208, 1621-1624.
2010
G Perona-Wright, K Mohrs and M Mohrs. Sustained signaling by canonical T helper cytokines throughout the reactive lymph node. Nat Immunology (2010) 11, 520-526. A synopsis was published as a Research Highlight in Nature Reviews Immunology (2010) 10, 382-383.
G Perona-Wright, K Mohrs, KD Mayer and M Mohrs. Differential regulation of IL-4Ra expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J Immunol (2010) 184, 615-623.
2009
G Perona-Wright, K Mohrs, FM Szaba, LW Kummer, R Madan, CL Karp, LL Johnson, ST Smiley and M Mohrs. Systemic but not local infections elicit immunosuppressive IL-10 production by Natural Killer cells. Cell Host & Microbe (2009) 6, 503-12. An accompanying commentary, written by Eric Vivier and Sophie Ugnoli, was published in the same issue.
B Everts, G Perona-Wright, HH Smits, CH Hokke, AJ van der Ham, CM Fitzsimmons, MJ Doenhoff, J van der Bosch, K Mohrs, H Haas, M Mohrs, M Yazdanbakhsh and G Schramm. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J Exp Med (2009) 206, 1673-80.
KN Couper, PA Lanthier, G Perona-Wright, LW Kummer, W Chen, ST Smiley, M Mohrs and LL Johnson. Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection. J Immunol (2009) 182, 3985-94.
G Perona-Wright, SJ Jenkins, RA O’Connor, D Zienkiewicz, HJ McSorley, RM Maizels, SM Anderton and AS MacDonald. A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. J Immunol (2009) 182, 2808-15.
2008
G Perona-Wright, K Mohrs, J Taylor, C Zaph, D Artis, EJ Pearce and M Mohrs. Helminth infection induces IgE in the absence of m or d chain expression. J Immunol (2008) 181, 6697-701.
SJ Jenkins, G Perona-Wright and AS MacDonald. Full development of Th2 immunity requires both innate and adaptive sources of CD154. J Immunol (2008) 180, 8083-92.
2007
SJ Jenkins, G Perona-Wright, AG Worsley, N Ishii and AS MacDonald. Dendritic cell expression of OX40L acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J Immunol (2007) 179, 3515-23.
S Mahajan, AM Cervera, M MacLeod, S Fillatreau, G Perona-Wright, S Meek, A Smith, AS MacDonald and D Gray. The role of ICOS in the development of CD4 T cell help and the re-activation of memory T cells. Eur J Immunol (2007) 37, 1796-808.
G Perona-Wright, SM Anderton, SE Howie and D Gray. IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease. Int Immunol (2007) 19, 1123-34.
2006
G Perona-Wright, SJ Jenkins, A Crawford, D Gray, EJ Pearce and AS MacDonald. Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol (2006) 36, 2367-75.
G Perona-Wright, SJ Jenkins and AS MacDonald. Dendritic cell activation and function in response to Schistosoma mansoni. Int J Parasitol (2006) 36, 711-21. A review article.
2002
MW Barnett, CE Fisher, G Perona-Wright and JA Davies. Signaling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan. J Cell Science (2002) 115, 4495-4503.
1998
G Fu, G Perona-Wright and DC Barker. Leishmania (V.) braziliensis: characterization of a complex specific repeat and its use in the detection of parasites. Exp Parasitol (1998) 90, 236-43.