Optimal immunity -

The best immune response is not always the strongest. Surviving an infection requires an immune response strong enough to kill the pathogen, but not so strong that the collateral damage kills the infected person too.

We're working to understand how that balance is achieved in infection and co-infection. We are particularly interested in the interaction between coincident, opposing immune signals. How does cytokine cross-talk impose immune balance, or dictate the outcome of infection? What are the environmental, tissue-based signals that determine the outcome of immune activity? Can immune metabolism be manipulated to control the immune response?

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